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A Review:Solid Dispersion, a Technique of Solubility Enhancement

Affiliations

  • Krupanidhi College of Pharmacy, Chikkabellandur Village, Carmelaram Post, Varthur Hobli, Bangalore - 560035, India

Abstract


Purpose: The aim of the study was to explore the necessity, advantages and different techniques of solid dispersion for enhancing solubility of poorly soluble drugs.

Approach: Different types of solid dispersion have been explained briefly along with the various techniques of solid dispersion in detail.

Findings: Solid dispersions of poorly soluble drugs have been found to give positive results in enhancing its solubility and dissolution characters.

Conclusion: Solid dispersion techniques improve solubility and bioavailability of poorly soluble drugs. Solid dispersions can be incorporated into various dosage forms with wide range of applicability.


Keywords

Solid Dispersion Techniques, Solubility, Advantages, Disadvantages, Carriers.

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References


  • Arunprasad K, Narayanan N, Rajalakshmi G. Preparation and evaluation of solid dispersion of Terbinafine Hydrochloride. Int J Pharm Sci Rev Res. 2010;3(1): 130-134
  • Rumondor A, Dhareshwar S, Kesisoglou F. Amorphous Solid Dispersions or Prodrugs: Complementary Strategies to Increase Drug Absorption. J Pharm Sci. 2016;105(9): 2498-2508.
  • Sun D.D, Lee P.I. Crosslinked hydrogels—a promising class of insoluble solid molecular dispersion carriers for enhancing the delivery of poorly soluble drugs. Acta Pharmaceutica Sinica B. 2014;4(1): 26-36.
  • Deshmukh D.B, Gaikwad P.D, Bankar V.H, Pawar S.P. Dissolution enhancement of poorly water soluble diacerein by solid dispersion technique. J Pharm Sci Res. 2010; 2(11): 734-739.
  • Dehghan M.H, Saifee M, Hanwate R.M. Comparative dissolution study of glipizide by solid dispersion technique. J Pharm Sci Technol. 2010;2(9): 293-297.
  • Yang G, Zhao Y, Feng N, Zhang Y, Liu Y, Dang B. Improved dissolution and bioavailability of silymarin delivered by a solid dispersion prepared using supercritical fluids. Asian J Pharm Sci. 2015;10(3): 194-202.
  • Mehta S, Joseph N.M, Feleke F, Palani S. Improving solubility of BCS class II drugs using solid dispersion. J Drug Deliv Ther. 2014;4(3): 7-13.
  • Sharma D, Soni M, Kumar S, Gupta G.D. Solubility enhancement–Eminent role in poorly soluble drugs. Res J Pharm Technol. 2009;2(2): 220-224.
  • Das S.K, Roy S, Kalimuthu Y, Khanam J, Nanda A. Solid dispersions: an approach to enhance the bioavailability of poorly water-soluble drugs. Int J Pharmacol Pharm Technol. 2012;1(1): 37-46.
  • Ankit M, Manish Y, Dinesh C. Solid dispersion: A technique to improve solubility of poorly water soluble drug. Indo Am J Pharm Res. 2014;4(6): 2855-2866.
  • Dixit ND, Niranjan SK. A Review: solid dispersion. World J Pharm Pharm Sci. 2014;3: 238-257.
  • Singh J, Walia M, Harikumar SL. Solubility enhancement by solid dispersion method: a review. J Drug Deliv Ther. 2013;3(5): 148-155.
  • Dixit AK, Singh RP, Singh S. Solid dispersion-a strategy for improving the solubility of poorly soluble drugs. Int J Res Pharm Biomed Sci. 2012;3(2): 960-966.
  • Yadav PS, Kumar V, Singh UP, Bhat HR, Mazumder B. Physicochemical characterization and in vitro dissolution studies of solid dispersions of ketoprofen with PVP K30 and D-mannitol. Saudi Pharm J. 2013;21(1): 77-84.
  • Chaulang G, Patil K, Ghodke D, Khan S, Yeole P. Preparation and characterization of solid dispersion tablet of furosemide with crospovidone. Res J Pharm Tech. 2008;1(4): 386-389.
  • Yadav B, Tanwar Y.S. Applications of solid dispersions. J Chem Pharm Res. 2015;7(2): 965-978
  • Sridhar I, Doshi A, Joshi B, Wankhede V, Doshi J. Solid dispersions: an approach to enhance solubility of poorly water soluble drug. J Sci Innov Res. 2013;2(3): 685-694.