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Effect of Methanolic Root Extracts of Ethnomedicinal Plants on Paracetamol Induced Hepatotoxicity in Rats

Affiliations

  • Dept. of Pharmacognosy, Government College of Pharmacy, Bangalore -560027, India

Abstract


Purpose : To evaluate the hepatoprotective activity of methanolic root extracts of Memecylon malabaricum (MM), Andrographis serpyllifolia (AS) and Leucas aspera (LA) against the paracetamol induced hepatotoxicity.

Approach : The methanolic root extracts of MM (family: Melastomaceae), AS (family: Acanthaceae) and LA (family: Lamiaceae) was studied at different doses and compared with standard Silymarin (25 mg/kg b.w). All the doses were administered orally. Thereafter, paracetamol induced hepatotoxicity in elevation of the serum levels of biochemical parameters like SGOT, SGPT, ALKP, TBL and CHL were studied.

Findings : The rats treated with the methanolic root extracts of MM, AS, LA and silymarin showed a significant (p<0.05) decrease in all the elevated SGOT, SGPT, ALKP, TBL, CHL and significant increase (p<0.05) in TPTN and ALB levels at dose dependent manner. Pretreatment with Silymarin and methanolic root extracts MM, AS and LA produced significant antihepatotoxic activity.

Conclusion : The reduction of elevated serum levels were explored by evaluated hepatoprotective activity of methanolic root extracts of MM, AS and LA against the paracetamol induced hepatotoxicity.


Keywords

Biochemical Parameters, Hepatoprotective, Hepatotoxicity, Medicinal Plants, Methanolic Extract.

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