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A Prospective, Randomized Controlled Study to Evaluate the Efficacy of Topical Flurbiprofen in Maintaining Intraoperative Mydriasis during Small Incision Cataract Surgery
A prospective, comparative study to evaluate the efficacy of topical flurbiprofen in maintaining intraoperative mydriasis during cataract surgery was conducted. A total of 70 patients, undergoing small incision cataract surgery (SICS) with IOL insertion were randomized into either of the two treatment groups. Pre-operatively patients of both the group had pupillary dilatation with topical application of cyclopentolate eye drops. In addition, flurbiprofen group received 0.03% Flurbiprofen eye drops thirty minutes apart starting two hours before surgery. Intra operative mydriasis was measured at different stages of surgery such as Stage I - before anterior chamber entry, Stage II - Between anterior chamber entry, anterior capsulotomy, and nucleus delivery, Stage III-Nucleus delivery to complete cortex wash. The mean pupillary diameter at baseline was equal in both control (7.57 ± 0.73) mm and (7.57 ±0.74) mm in Flurbiprofen groups. Standard error of mean of maintained intraoperative mydriasis in control vs. flurbiprofen group were: Stage I 7.08 ± 0.50mm vs. 7.00 ± 0.93, Stage II- 5.37 ± 1.47mm vs. 5.74 ± 0.91mm and Stage III-4.28 ± 1.27mm vs. 4.00 ± 1.30mm which were not significant statistically. This study indicates that topical Flurbiprofen is not significantly effective in maintaining pupillary dilatation during SICS, compared to control group.
Small Incision Cataract Surgery, Flurbiprofen, Intraoperative Mydriasis.